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  • Title: Studies on 15-hydroxyprostaglandin dehydrogenase with various prostaglandin analogues.
    Author: Ohno H, Morikawa Y, Hirata F.
    Journal: J Biochem; 1978 Dec; 84(6):1485-94. PubMed ID: 216666.
    Abstract:
    The NAD+-linked 15-hydroxyprostaglandin dehydrogenase (PGDH) of swine lung was purified to a high specific activity by affinity chromatographies on prostaglandin (PG)-and NAD+-Sepharose. The affinities of the enzyme for various synthetic analogues of PGA, E, F, and I and their inhibitory effects on the enzymatic reaction were examined. The modification of the alkyl side chain of PG, particularly at C-15 or C-16, reduced the affinity of the enzyme for these PG analogues. Furthermore, 14-methyl-13,14-dihydro-PGE1 and 16-cyclopentyl-omega-trinor-15-epi-PGE2 were potent inhibitors of PGDH.
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