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  • Title: Polypeptide specificity of antiviral serum antibodies in children naturally infected with human rotavirus.
    Author: Brüssow H, Offit PA, Gerna G, Bruttin A, Sidoti J.
    Journal: J Virol; 1990 Sep; 64(9):4130-6. PubMed ID: 2166808.
    Abstract:
    Reassortants between serotype 3 SA11 and serotype 6 NCDV rotaviruses were used to determine the relative amounts of serum-neutralizing antibody to VP4 and VP7 of serotype 3 SA11 rotavirus in children after natural rotavirus exposure. Sera from Ecuadorian children of a population-based study and sera from children of a hospital-based study in Germany (excluding diarrhea patients) demonstrated high titers of VP7-specific but only low titers of VP4-specific antibodies. In contrast, paired sera from German children hospitalized with a symptomatic primary rotavirus gastroenteritis demonstrated a titer increase to VP4 more frequently than to VP7 protein by neutralization test and immunoblotting. For these rotavirus patients, we provided, previously, direct evidence for the development of cross-neutralizing antibodies.
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