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  • Title: Human papillomavirus genotype distribution among French women with and without cervical abnormalities.
    Author: Casalegno JS, Benchaib M, Le Bail Carval K, Piaton E, Mathevet P, Mekki Y.
    Journal: Int J Gynaecol Obstet; 2011 Aug; 114(2):116-9. PubMed ID: 21669421.
    Abstract:
    OBJECTIVE: To assess human papillomavirus (HPV) prevalence and distribution among French women with normal and pathologic cytology findings. METHODS: A genomic DNA microarray assay enabling the detection of 35 different HPV genotypes was used for in vitro diagnosis, as a complement to Papanicolaou screening, to test 785 women who attended the gynecology department of a hospital in Lyon, France. RESULTS: Pathologic and normal cytology findings were obtained for 260 (33.1%) and 302 (38.5%) of the 785 women, respectively, whereas 223 (28.4%) results were inconclusive. HPV infection and multiple infection were significantly more prevalent (P<0.001) in the population with pathologic findings (90.0% and 41.9%, respectively) than in the population with normal cytology findings (48.3% and 20.2%, respectively). Overall, the 4 most frequent HPV genotypes were HPV-16 (14.8%), HPV-53 (9.0%), HPV-31 (8.7%), and HPV-51 (7.5%), whereas HPV-18 (3.8%), HPV-6 (2.9%), and HPV-11 (0.4%) were less common. The HPV genotypes included in the quadrivalent vaccination had a prevalence of 20.6% among all women and 30.4% among those with pathologic findings. CONCLUSION: The present data indicate a reduced direct impact of HPV vaccination in the study population owing to a low prevalence of HPV-18 and a high prevalence of HPV-53, HPV-31, and HPV-51.
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