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  • Title: Synthesis and activities of naphthalimide azoles as a new type of antibacterial and antifungal agents.
    Author: Zhang YY, Zhou CH.
    Journal: Bioorg Med Chem Lett; 2011 Jul 15; 21(14):4349-52. PubMed ID: 21669530.
    Abstract:
    Naphthalimide-derived azoles as a new type of antimicrobial agents were synthesized and evaluated for their efficiency in vitro against eight bacteria and two fungi by two fold serial dilution technique. Most title compounds exhibited good antimicrobial potency with low MIC values ranging from 1 to 16μg/mL. Notably, some synthesized compounds displayed comparable or even better antibacterial and antifungal activities against some tested strains than the reference drugs Orbifloxacin, Chloromycin and Fluconazole, respectively.
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