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  • Title: Carnosine as a potential scavenger of oxidants generated by stimulated neutrophils.
    Author: Sharonov BP, Govorova NJu, Lyzlova SN.
    Journal: Biochem Int; 1990; 21(1):61-8. PubMed ID: 2167089.
    Abstract:
    Luminol-dependent chemiluminescence of PMA-stimulated human neutrophils decrease more than by 50% in the presence of physiological concentrations of carnosine (20 mM). This inhibition is the result of carnosine ability to scavenge hypochlorite (OCl-), since carnosine exerts a similar effect on chemiluminescence produced by myeloperoxidase-H2O2-Cl- and OCl(-)-H2O2 systems. The previously undocumented property of this dipeptide to scavenge active oxygen species requires further experiments.
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