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  • Title: sp3 C-H bond activation with ruthenium(II) catalysts and C(3)-alkylation of cyclic amines.
    Author: Sundararaju B, Achard M, Sharma GV, Bruneau C.
    Journal: J Am Chem Soc; 2011 Jul 13; 133(27):10340-3. PubMed ID: 21671630.
    Abstract:
    A selective C(3)-alkylation via activation/functionalization of sp(3) C-H bond of saturated cyclic amines was promoted by (arene)ruthenium(II) complexes featuring a bidentate phosphino-sulfonate ligand upon reaction with aldehydes. This highly regioselective sustainable transformation takes place via initial dehydrogenation of cyclic amines and hydrogen autotransfer processes.
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