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Title: sp3 C-H bond activation with ruthenium(II) catalysts and C(3)-alkylation of cyclic amines. Author: Sundararaju B, Achard M, Sharma GV, Bruneau C. Journal: J Am Chem Soc; 2011 Jul 13; 133(27):10340-3. PubMed ID: 21671630. Abstract: A selective C(3)-alkylation via activation/functionalization of sp(3) C-H bond of saturated cyclic amines was promoted by (arene)ruthenium(II) complexes featuring a bidentate phosphino-sulfonate ligand upon reaction with aldehydes. This highly regioselective sustainable transformation takes place via initial dehydrogenation of cyclic amines and hydrogen autotransfer processes.[Abstract] [Full Text] [Related] [New Search]