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  • Title: The effect of MK-801 on the micturition reflex in anesthetized rats.
    Author: Maggi CA, Giuliani S, Giachetti A, Meli A.
    Journal: Eur J Pharmacol; 1990 May 31; 181(1-2):105-9. PubMed ID: 2167227.
    Abstract:
    We studied the effect of MK-801, a potent non-competitive NMDA receptor antagonist, on the micturition reflex in anesthetized rats. Pretreatment with MK-801 (0.1-1 mg/kg i.v.) dose dependently increased the bladder capacity and reduced the micturition contraction. The ability of MK-801 to inhibit bladder voiding was confirmed in additional experiments in which the compound (30-50 micrograms/kg i.v.) transiently suppressed established bladder voiding produced by continuous bladder filling. MK-801 (1 microM) did not affect nerve-mediated contractions of the rat bladder or inhibit the response to capsaicin. These findings provide pharmacological evidence for an involvement of NMDA receptors in the micturition reflex pathways.
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