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  • Title: Recurrent tubulointerstitial nephritis and uveitis syndrome in a renal transplant recipient.
    Author: Onyekpe I, Shenoy M, Denley H, Riad H, Webb NJ.
    Journal: Nephrol Dial Transplant; 2011 Sep; 26(9):3060-2. PubMed ID: 21673077.
    Abstract:
    We report for the time a patient with recurrence of tubulointerstitial nephritis and uveitis (TINU) following renal transplantation. Our patient was diagnosed at the age of 8 years and, despite treatment with systemic steroids, developed established renal failure. At the age of 17 years, he underwent a live-related donor renal transplant. Immunosuppression included tacrolimus, mycophenolate mofetil and prednisolone. Having had normal renal function for 3 years after transplantation, he developed uveitis and decline in the graft function. A biopsy of the allograft demonstrated recurrent granulomatous interstitial nephritis. The recurrence of TINU following transplantation suggests a role for circulating autoantibodies in the disease pathology.
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