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  • Title: Time course of alpha 2-adrenoceptor desensitization induced by adrenaline infusion in man.
    Author: Lübbecke F, Zschätzsch S, Mitrovic V, Husseini H, Schütterle G, Wizemann V.
    Journal: Pharmacology; 1990; 40(4):231-5. PubMed ID: 2167486.
    Abstract:
    After a rapid increase in infusion rate of adrenaline to elevate the initial heart rate by more than 15%, a continuous infusion was sustained in order to maintain elevated adrenaline plasma levels. At the end of the first phase of the experiment, the thrombocyte alpha 2-adrenoceptor number (determined by radioligand binding) was significantly lowered. After the second part of the experiment, a further significant decrease in the density of binding sites was observed, while elevated adrenaline plasma levels were kept constant. The decrease in the number of binding sites was accompanied by a slight increase in affinity of the radioligand. Serum potassium concentration significantly decreased during the experiment, while other serum electrolytes showed no significant alterations.
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