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  • Title: [Quantum-chemical investigation of the elementary molecular mechanisms of pyrimidine-purine transversions].
    Author: Brovarets' OO, Govorun D M.
    Journal: Ukr Biokhim Zh (1999); 2010; 82(5):57-67. PubMed ID: 21674962.
    Abstract:
    Purine-purine mispairs of DNA (thus involving template base in anti-conformation along the glycosidic bond and base of the incoming nucleotide - in syn-conformation) leading to pyrimidine-purine "transversions"-type point mutations were revealed and characterized at the MP2/6-311++G(2df,pd)//B3LYP/6-311++G(d,p) level of theory in vacuum approach adequately modeling hydrophobic environment of the active centre of high-fidelity replicative DNA-polymerases.
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