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  • Title: Sensitivity in vitro of Giardia intestinalis to dyadic combinations of azithromycin, doxycycline, mefloquine, tinidazole and furazolidone.
    Author: Crouch AA, Seow WK, Whitman LM, Thong YH.
    Journal: Trans R Soc Trop Med Hyg; 1990; 84(2):246-8. PubMed ID: 2167523.
    Abstract:
    The new macrolide antibiotic, azithromycin, produced significant growth inhibition of Giardia intestinalis at 100 micrograms/ml, but adherence inhibition was significant at concentrations as low as 1 microgram/ml for the two strains used in these experiments. The dyadic combinations of azithromycin-furazolidone, doxycycline-mefloquine, doxycycline-tinidazole and mefloquine-tinidazole were synergistic for inhibition of adherence. These results suggest that these dyadic combinations may be worthy of consideration for chemotherapy of recalcitrant giardiasis.
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