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  • Title: The novel inositol lipid phosphatidylinositol 3,4-bisphosphate is produced by human blood platelets upon thrombin stimulation.
    Author: Sultan C, Breton M, Mauco G, Grondin P, Plantavid M, Chap H.
    Journal: Biochem J; 1990 Aug 01; 269(3):831-4. PubMed ID: 2167665.
    Abstract:
    Radioactive PtdIns(3)P was detected in human platelets incubated with [32P]Pi, but remained unaffected by thrombin treatment. In contrast, [32P]PtdIns(3,4)P2 was absent from resting platelets, but was produced by thrombin-activated platelets in a dose- and time-dependent manner. [32P]PtdInsP3 was never found under these conditions. These changes are similar to those elicited in other cells by platelet-derived growth factor or the oncogene product pp60c-src.
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