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  • Title: Positive Epstein-Barr virus and cytomegalovirus IgM assays in primary HIV infection.
    Author: Post JJ, Chan MK, Whybin LR, Shi Q, Rawlinson WD, Cunningham P, Robertson PW.
    Journal: J Med Virol; 2011 Aug; 83(8):1406-9. PubMed ID: 21678445.
    Abstract:
    We report three cases with misleading cytomegalovirus (CMV) or Epstein-Barr virus (EBV) immunoglobulin M (IgM) results during primary human immunodeficiency virus (HIV) infection. We determined the rate of positive anti-CMV IgM assays or anti-EBV capsid antigen IgM assays in sera from a group of well-characterized subjects with primary HIV infection as 2.9% (1/35; 95%CI: 0.15-16.6%) for each infection. The rate of positive anti-EBV capsid antigen IgM assays in subjects with positive hepatitis A virus IgM assays was 30% (6/20; 95%CI: 14.6-51.9%). Clinicians need to consider the limitations of IgM assays for diagnosis of herpesvirus infections, and consider testing for other infections with overlapping clinical manifestations.
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