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  • Title: [Influence of fluoxetine and paroxetine on anxiety-like behavior in young and adult prenatally stressed male rats].
    Author: Pivina SG, Fedotova YO, Akulova VK, Ordian NÉ.
    Journal: Eksp Klin Farmakol; 2011; 74(4):3-5. PubMed ID: 21678650.
    Abstract:
    We present the results of a comparative analysis of the effects of the chronic administration of the selective serotonin reuptake inhibitors fluoxetine (5.0 mg/kg, p.o.) and paroxetine (5.0 mg/kg, p.o.) for 14 days of the postnatal period on anxiety-like behavior in the prenatally stressed male rats as studied during pubertal period (1.5 month) and in the adult age (3 month). The chronic administration of paroxetine in male rats did not change the anxiety-like behavior in male rates of any age. On the contrary, the administration of fluoxetine modulated the anxiety-like behavior of prenatally stressed rats depending on the age: the anxiolytic effect was observed in young males, while the anxiogenic effect was observed in adult male rats.
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