These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Biological activities of synthetic peptides of the sequence of human interferon-alpha.
    Author: Eichmann E, Majarov VA, Kozhich AT, Noll F, Zav'yalov VP.
    Journal: Immunol Lett; 1990 Jul; 24(4):233-6. PubMed ID: 2167875.
    Abstract:
    Theoretical and experimental data were obtained indicating a possible role of the amino acid sequence 69-80 of HuIFN-alpha for antiviral activity of interferon. In this paper, synthetic peptides (penta-, octa- and dodecapeptides), representing the sequence region of positions 69-80 of the primary structure of HuIFN-alpha-2 were investigated with regard to their ability to inhibit the cytopathic effect of VSV on MDBK cells and on embryonic human fibroblasts. The peptides themselves exhibit only a very weak antiviral activity; however, it was found that these peptides even increase the antiviral activity of HuIFN-alpha-2.
    [Abstract] [Full Text] [Related] [New Search]