These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Analysis of the role of the extracellular domain of the v-erbB oncogene in cellular transformation.
    Author: Lee EB, Hayman MJ.
    Journal: Oncogene; 1990 Aug; 5(8):1165-72. PubMed ID: 2168029.
    Abstract:
    The role of the extracellular domain of the v-erbB oncogene in the transformation of chicken fibroblasts and erythroblasts has been examined. A virus was isolated in which the complete extracellular domain and the transmembrane domain of the v-erbB were replaced with sequences from the gag and env genes. The resulting virus, GEE35, was capable of transforming both fibroblasts and erythroblasts as efficiently as wild-type v-erbB. Biochemical and immunochemical analysis of the v-erbB protein encoded by GEE35 revealed two proteins of apparent molecular weights of approximately 130,000 daltons. One of these proteins was an N-linked glycosylated membrane protein, whereas the other was cytoplasmic. The possible roles of either of these two proteins in transformation is discussed.
    [Abstract] [Full Text] [Related] [New Search]