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  • Title: The missing C-17 O-methyltransferase in geldanamycin biosynthesis.
    Author: Yin M, Lu T, Zhao LX, Chen Y, Huang SX, Lohman JR, Xu LH, Jiang CL, Shen B.
    Journal: Org Lett; 2011 Jul 15; 13(14):3726-9. PubMed ID: 21682254.
    Abstract:
    The biosynthetic gene clusters for the Hsp90 inhibitor geldanamycin (GDM, 1) have been cloned previously from three different Streptomyces strains, but the gene encoding the C-17 O-methyltransferase remains unknown. The cloning and sequencing of a new GDM biosynthetic gene cluster from Streptomyces autolyticus CGMCC 0516 was reported, identifying the gdmMT gene that encodes the missing C-17 O-methyltransferase for 1 biosynthesis.
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