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  • Title: Food dependence in rats selectively bred for low versus high saccharin intake. Implications for "food addiction".
    Author: Yakovenko V, Speidel ER, Chapman CD, Dess NK.
    Journal: Appetite; 2011 Oct; 57(2):397-400. PubMed ID: 21683748.
    Abstract:
    The "food addiction" concept implies that proneness to drug dependence and to food dependence should covary. The latter was studied in low- (LoS) and high- (HiS) saccharin-consuming rats, who differ in drug self-administration (HiS>LoS) and withdrawal (LoS>HiS). Sugary food intake in the first 1-2 h was higher in HiS than LoS rats. Sugar intake predicted startle during abstinence only among LoS rats. These results may suggest bingeing-proneness in HiS rats and withdrawal-proneness among LoS rats. However, intake escalation and somatic withdrawal did not differ between lines. Further study with selectively bred rats, with attention to definitions and measures, is warranted.
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