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  • Title: Natural products as catalysts for innovation: a pharmaceutical industry perspective.
    Author: Schmitt EK, Moore CM, Krastel P, Petersen F.
    Journal: Curr Opin Chem Biol; 2011 Aug; 15(4):497-504. PubMed ID: 21684800.
    Abstract:
    Natural products are evolutionarily designed and chemically distinct from most synthetic library molecules. In addition to their role as drugs, they are successfully used as molecular probes to identify disease relevant targets. Novel natural products are still routinely discovered from traditional sources through cultivation of microorganisms. Complementary approaches based on genome sequence information and subsequent annotation of biosynthetic pathways are emerging technologies. However, to be of practical use for drug discovery, these concepts must be advanced beyond their current state.
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