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  • Title: Antiinflammatory properties of the new antirheumatic agent 4-acetylaminophenylacetic acid.
    Author: Fujisawa H, Nishimura T, Inoue Y, Ogaya S, Shibata Y, Nakagawa Y, Sato S, Kimura K.
    Journal: Arzneimittelforschung; 1990 Jun; 40(6):693-7. PubMed ID: 2168705.
    Abstract:
    The antiinflammatory activity of 4-acetylaminophenylacetic acid (MS-932) was investigated. MS-932 did not suppress the acute inflammation of carrageenin-induced paw edema in rats or of primary swelling in adjuvant arthritic rats. However, prophylactic treatment with MS-932 inhibited secondary inflammation in adjuvant arthritic rats. MS-932 also restored to normal the weight of the spleen and the serum albumin/globulin ratio of adjuvant arthritic rats. In addition to its prophylactic effect, MS-932 had a therapeutic effect on adjuvant arthritis. In in vitro tests, MS-932 did not inhibit prostaglandin E2 biosynthesis from arachidonic acid by sheep seminal vesicle microsomal enzyme or superoxide generation by guinea pig neutrophils stimulated with opsonized zymosan. MS-932 had no analgesic effect in mice and no antipyretic effect in rats. These results indicate that MS-932 suppresses adjuvant arthritis through modulation of the immune system.
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