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  • Title: Fetal protection against bovine viral diarrhoea type 1 virus infection after one administration of a live-attenuated vaccine.
    Author: Meyer G, Deplanche M, Roux D, Moulignie M, Picard-Hagen N, Lyazrhi F, Raboisson D, Mathevet P, Schelcher F.
    Journal: Vet J; 2012 May; 192(2):242-5. PubMed ID: 21689959.
    Abstract:
    A modified-live vaccine has been shown previously to prevent fetal infection with bovine viral diarrhoea virus (BVDV)-2 and, to some extent BVDV-1, when used in association with an inactivated vaccine in a two-step vaccination protocol. In this challenge study, the modified-live vaccine used alone was able to protect 13 heifers between 49 and 96 days of gestation at challenge from leucopenia and virus replication and, for a 4-month period, to prevent fetal infection. The efficacy of the BVDV-1f 22146/Han81 challenge was demonstrated by virus isolation from the fetuses of all nine non-vaccinated, control heifers. However, the small number of heifers tested meant that the vaccination failure rate could be as high as 10% in the field.
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