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  • Title: Effects of n-3 polyunsaturated fatty acids on hepatic tight junction after partial hepatectomy in rats.
    Author: Qiu Y, Wang M, Tan T, Yuan X, Ding Y.
    Journal: Transplant Proc; 2011 Jun; 43(5):1480-3. PubMed ID: 21693221.
    Abstract:
    OBJECTIVE: To explore the effects of n-3 polyunsaturated fatty acid (PUFA) on the hepatic tight junction in rat liver after partial hepatectomy. MATERIALS AND METHODS: Male Sprague-Dawley rats were divided into 4 groups: sham operation, 70% hepatectomy, 70% hepatectomy with administration of 1 mL/kg n-3 PUFA, and 70% hepatectomy with administration of 2 mL/kg n-3 PUFA. Morphologic features of the hepatic tight junction were observed at transmission electron microscopy, and expression of the tight junction proteins occludin, claudin-3, and ZO-1 was studied using Western blot analysis. RESULTS: The hepatic tight junction structure became loosened 3 days after 70% hepatectomy. The levels of tight junction occludin decreased markedly, whereas claudin-3 and ZO-1 levels increased 2- or 3-fold over control levels. Supplementation of n-3 PUFA alleviated the changes in tight junction structure and occludin expression. CONCLUSION: n-3 PUFA has protective effects on hepatic tight junction structure after 70% hepatectomy, which were attributed in part to modulation of occludin expression.
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