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  • Title: Fetal and maternal levels of corticosterone and ACTH after pharmacological adrenalectomy.
    Author: Baram TZ, Schultz L.
    Journal: Life Sci; 1990; 47(6):485-9. PubMed ID: 2169559.
    Abstract:
    A paradigm of pharmacological adrenalectomy of pregnant rats and fetuses in utero is described. A regimen of twice daily metyrapone injections (10 mg/100 gm body weight), results in marked depression of serum corticosterone in pregnant and in fetal rats without surgical trauma and stress. The technique should be useful in a wide variety of studies involving the developing brain-adrenal axis.
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