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  • Title: A generalized strategy for designing (19)F/(1)H dual-frequency MRI coil for small animal imaging at 4.7 Tesla.
    Author: Hu L, Hockett FD, Chen J, Zhang L, Caruthers SD, Lanza GM, Wickline SA.
    Journal: J Magn Reson Imaging; 2011 Jul; 34(1):245-52. PubMed ID: 21698714.
    Abstract:
    PURPOSE: To propose and test a universal strategy for building (19) F/(1) H dual-frequency RF coil that permits multiple coil geometries. MATERIALS AND METHODS: The feasibility to design (19) F/(1) H dual-frequency RF coil based on coupled resonator model was investigated. A series capacitive matching network enables robust impedance matching for both harmonic oscillating modes of the coupled resonator. Two typical designs of (19) F/(1) H volume coils (birdcage and saddle) at 4.7T were implemented and evaluated with electrical bench test and in vivo (19) F/(1) H dual-nuclei imaging. RESULTS: For various combinations of internal resistances of the sample coil and secondary resonator, numerical solutions for the tunable capacitors to optimize impedance matching were obtained using a root-seeking program. Identical and homogeneous B1 field distribution at (19) F and (1) H frequencies were observed in bench test and phantom image. Finally, in vivo mouse imaging confirmed the sensitivity and homogeneity of the (19) F/(1) H dual-frequency coil design. CONCLUSION: A generalized strategy for designing (19) F/(1) H dual-frequency coils based on the coupled resonator approach was developed and validated. A unique feature of this design is that it preserves the B1 field homogeneity of the RF coil at both resonant frequencies. Thus it minimizes the susceptibility effect on image co-registration.
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