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  • Title: Antagonism of swim-stress-induced antinociception by the delta-opioid receptor antagonist naltrindole in adult and young rats.
    Author: Kitchen I, Pinker SR.
    Journal: Br J Pharmacol; 1990 Aug; 100(4):685-8. PubMed ID: 2169936.
    Abstract:
    1. The availability of the non-peptide delta-opioid receptor antagonist naltrindole has provided the possibility for in vivo studies on the function of delta-opioid receptors. We have studied the effects of naltrindole on swim-stress-induced antinociception in adult and neonatal rats. 2. Adult, 25 and 20 day old rats were stressed by warm water (20 degrees C) swimming for 3 min periods and antinociception was assessed by the tail immersion test (50 degrees C). 3. Naltrindole (0.5 and 1 mg kg-1) antagonized swim-stress-induced antinociception in adult and 25 day old rats but in 20 day old rats naltrindole (1 mg kg-1) was without effect. 4. Antinociception induced by the highly mu-opioid receptor selective agonist alfentanil was completely antagonized by naloxone (1 mg kg-1) but virtually unaffected by naltrindole (1 mg kg-1). 5. Neither naloxone nor naltrindole (1 mg kg-1) antagonized swim-stress-induced rises in plasma corticosterone in adult rats at the time of peak antinociception. 6. In conclusion, naltrindole shows in vivo antagonism of opioid-mediated responses. Swim-stress-induced antinociception is mediated through the delta-opioid receptor in 25 day old and adult rats and through the mu-opioid site in 20 day old animals.
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