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  • Title: [Antifungal agents in dermatophytic disease: failure of griseofulvin, ketoconazole and itraconazole].
    Author: Boudghène-Stambouli O, Mérad-Boudia A.
    Journal: Bull Soc Pathol Exot; 1990; 83(2):170-6. PubMed ID: 2170041.
    Abstract:
    The dermatophytic disease is a rare, severe affection caused by banal dermatophytes. A genetically predisposed basis could explain the frequent failure of antifungal therapeutics. We report here the case of a 28-year-old male. Despite 2 years of griseofulvin, 23 months of ketoconazole and 8 months of itraconazole, the therapeutic failure was evident: circinate herpes, papulo-nodules, vegetating plaques, ulceration, superficial and profound adenopathies, cerebral involvement, and deterioration of the general state. The correction of the immuno-deficient state combined with antifungals could be the best therapy.
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