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  • Title: A detailed meta-analysis shows no association between TNF-α -308G/A polymorphism and different forms of glaucoma.
    Author: Yu QQ, Yao Y.
    Journal: Ophthalmic Res; 2012; 47(1):47-51. PubMed ID: 21701244.
    Abstract:
    OBJECTIVE: Glaucoma is the second leading cause of blindness worldwide. To date, several publications have evaluated the association between the tumor necrosis factor α (TNF-α) -308G/A polymorphism and glaucoma risk. However, the results remain inconclusive. The aim of our study was to clarify the effect of the TNF-α -308G/A polymorphism on glaucoma risk. METHOD: We conducted searches of the published literature in the PubMed database updated to May 2010. A meta-analysis was performed by critically reviewing 7 publications with a total of 1,199 glaucoma cases and 1,189 controls on the -308G/A polymorphism. Odds ratio (OR) and 95% confidence intervals (CIs) were used to assess the strength of this relationship. RESULTS: Overall, no association between the TNF-α -308G/A polymorphism and primary open-angle glaucoma or pseudoexfoliation glaucoma risk was found in the A allele versus G allele genetic model (OR = 1.68, 95% CI = 0.78-3.59 or OR = 2.44, 95% CI = 0.40-15.04, respectively), the same as genetic models in AG versus GG and AA + AG versus GG. In the stratified analysis by ethnicity and source of control subgroups, a significant association was still not observed in all genetic models. CONCLUSION: Our meta-analysis provides strong evidence that the TNF-α -308G/A polymorphism is not associated with different forms of glaucoma risk.
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