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  • Title: Acquired myasthenia gravis and cholangiocellular carcinoma in a dog.
    Author: Krotje LJ, Fix AS, Potthoff AD.
    Journal: J Am Vet Med Assoc; 1990 Aug 15; 197(4):488-90. PubMed ID: 2170311.
    Abstract:
    Acquired myasthenia gravis and cholangiocellular carcinoma were diagnosed in a 7-year-old English Setter referred because of forelimb lameness, exercise-induced weakness, and fever. Three months earlier, the dog had had a pleuropulmonary infection caused by a Fusobacterium sp. The concurrent development of myasthenia gravis and cholangiocellular carcinoma in this dog may be explained by a paraneoplastic syndrome, although it is unproven. The cholangiocellular carcinoma may have possessed an acetylcholine receptor-like antigen on the tumor surface, which induced autoantibodies to cross-react with acetylcholine receptors at the neuromuscular junction.
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