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  • Title: Structure-based druggability assessment--identifying suitable targets for small molecule therapeutics.
    Author: Fauman EB, Rai BK, Huang ES.
    Journal: Curr Opin Chem Biol; 2011 Aug; 15(4):463-8. PubMed ID: 21704549.
    Abstract:
    A target is druggable if it can be modulated in vivo by a drug-like molecule. The general properties of oral drugs are summarized by the 'rule of 5' which specifies parameters related to size and lipophilicity. Structure-based target druggability assessment consists of predicting ligand-binding sites on the protein that are complementary to these drug-like properties. Automated identification of ligand-binding sites can use geometrical considerations alone or include specific physicochemical properties of the protein surface. Features of a pocket's size and shape, together with measures of its hydrophobicity, are most informative in identifying suitable drug-binding pockets. The recent availability of several validation sets of druggable versus undruggable targets has helped fuel the development of more elaborate methods.
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