These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Determination of N-methylcarbamate insecticides in water samples using dispersive liquid-liquid microextraction and HPLC with the aid of experimental design and desirability function.
    Author: Khodadoust S, Hadjmohammadi M.
    Journal: Anal Chim Acta; 2011 Aug 05; 699(1):113-9. PubMed ID: 21704765.
    Abstract:
    A rapid and simple method for the extraction and preconcentration of N-methylcarbamates (NMCs) (carbofuran, carbaryl and promecarb) in water samples using dispersive liquid-liquid microextraction (DLLME) using chemometrics was developed. Influence variables such as volume of extracting (CHCl(3)) and dispersing solvents (ACN), pH and ionic strength, extraction time and centrifugation time and speed were screened in a 2(7-4) Plackett-Burman design was investigated. The significant variables were optimized by using a central composite design (CCD) combined with desirability function (DF). At optimum conditions values of variables set as 126 μL chloroform, 1.5 mL acetonitrile, 1 min extraction time, 10 min centrifugation at 4000 rpm min(-1), natural pH, 4.7% (w/v) NaCl, the separation was reached in less than 14 min using a C(18) column and an isocratic binary mobile phase (acetonitrile: water (50:50, v/v)) with flow rate of 1.0 mL min(-1). At optimum conditions method has linear response over 0.001-10 μg mL(-1) with detection limit between 0.0001 and 0.0005 μg mL(-1) with relative standard deviations (RSDs) in the range 2.18-5.06% (n=6).
    [Abstract] [Full Text] [Related] [New Search]