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  • Title: Comparison of the effect of interleukin 6 and interleukin 1 on collagenase and proteoglycan production by chondrocytes.
    Author: Kandel RA, Petelycky M, Dinarello CA, Minden M, Pritzker KP, Cruz TF.
    Journal: J Rheumatol; 1990 Jul; 17(7):953-7. PubMed ID: 2170644.
    Abstract:
    In order to determine whether interleukin 6 (IL-6) is involved in the pathogenesis of the cartilage destruction observed in arthritis, the effect of human recombinant IL-6 on collagenase production and proteoglycan synthesis by bovine articular chondrocytes was examined. Addition of IL-6 (1.0 to 1000 U/ml) to the culture medium did not stimulate collagenase production or alter proteoglycan secretion. Whereas human purified interleukin 1 (IL-1) (20 U/ml) stimulated collagenase production and inhibited proteoglycan synthesis. Furthermore addition of IL-1 (20 U/ml) to chondrocyte cultures did not stimulate the chondrocytes to produce IL-6. Under our experimental conditions, IL-6 did not stimulate chondrocytes to proliferate as measured by [3H] thymidine incorporation. This would suggest that IL-6 is not involved in mediating cartilage loss.
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