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  • Title: Increases in alpha-but not beta-adrenoceptors in hypertrophied non-infarcted cardiac muscles from rats with chronic myocardial infarction.
    Author: Itaya T, Hashimoto H, Satoh R, Uematsu T, Nakashima M.
    Journal: Jpn J Pharmacol; 1990 Aug; 53(4):513-8. PubMed ID: 2170725.
    Abstract:
    The alteration in adrenoceptors in the hypertrophied right ventricle of the rats with myocardial infarction (Ml) was examined. The density of alpha-1-adrenoceptors increased in four and twelve week old Ml rats but not in one week old Ml rats. The beta-adrenoceptors did not significantly change. It is probable that the increased density of alpha-adrenoceptors may be one of the causes for the increased responsiveness to the alpha-adrenergic agonist in the hypertrophied cardiac muscles of Ml rats.
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