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  • Title: Morphologic and clinical aspects of estrogen receptors in carcinoma of the breast.
    Author: Kern WH.
    Journal: Surg Gynecol Obstet; 1979 Feb; 148(2):240-2. PubMed ID: 217114.
    Abstract:
    Morphological and cytologic features and preliminary survival data were correlated with the presence or absence of estrogen receptor protein in tissues from 123 primary and 26 metastatic carcinomas of the breast. The estrogen receptor positive tumors were somewhat smaller, 2.8 centimeters in diameter, than the estrogen receptor negative tumors, 3.2 centimeters, but the rate of axillary lymph node metastasis was similar. Fifty-eight per cent of the infiltrating ductal carcinomas, 64 per cent of 11 infiltrating lobular carcinomas and all eight less common cell types including: four mucinous; two papillary; one adenoid cystic, and one tubular carcinoma were estrogen receptor positive. Twenty-one of 33 aspiration smears performed were cytologically positive, the remaining 12 suspected of being carcinoma. Eleven of the 13 estrogen receptor negative tumors that were aspirated were positive possibly due to a lesser differentiation. Sixty per cent of the patients who nine to 40 months after operation are living without known recurrent disease had estrogen receptor positive tumors, but only 28 per cent of the 18 patients who have died of carcinoma of the breast or are living with known recurrent disease were in this category, suggesting that, in spite of a similar rate of axillary lymph node metastasis and without regard to the modality of treatment, estrogen receptor negative tumors tend to have a less favorable course.
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