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  • Title: [The cytolytic function of mononuclear phagocytes. I. The dependence of the mechanisms regulating and realizing the cytolytic function of macrophages on their origin and the mode of activation].
    Author: Krotkova MV, Popova EV, Kalatskiĭ IuM, Ageeva OG, Vasil'ev VIu.
    Journal: Tsitologiia; 1990; 32(3):266-74. PubMed ID: 2171173.
    Abstract:
    It has been shown that the induction of cytolytic activity in macrophages cause remarkable metabolic and morpho-structural shifts in effector cells, such as: 1) an expression of trypsin-sensitive receptors responsible for macrophage binding to malignant cells; 2) some differences in macrophage sensitivity to the cAMP system modifiers dependent on the activation inducer nature; 3) an enhanced production of oxygen metabolites directly involved in oxygen-dependent cytotoxicity of macrophages; 4) augmentation of lysosomal contents and activation of lysosomal enzymes. The inhibitor analysis enabled us to identify the main lytic components acting in the process of cytolytic functioning of macrophages of different origin and activation.
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