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  • Title: Fmoc synthesis of peptide thioesters without post-chain-assembly manipulation.
    Author: Zheng JS, Chang HN, Wang FL, Liu L.
    Journal: J Am Chem Soc; 2011 Jul 27; 133(29):11080-3. PubMed ID: 21714552.
    Abstract:
    An operationally simple method for the synthesis of peptide thioesters is developed using standard Fmoc solid-phase peptide synthesis procedures. The method relies on the use of a premade enamide-containing amino acid which, in the final TFA cleavage step, renders the desired thioester functionality through an irreversible intramolecular N-to-S acyl transfer.
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