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  • Title: Sensing amyloid-β aggregation using luminescent dipyridophenazine ruthenium(II) complexes.
    Author: Cook NP, Torres V, Jain D, Martí AA.
    Journal: J Am Chem Soc; 2011 Jul 27; 133(29):11121-3. PubMed ID: 21714574.
    Abstract:
    The aggregation of amyloid-β (Aβ) peptides has been associated with the onset of Alzheimer's disease. Here, we report the use of a luminescent dipyridophenazine ruthenium(II) complex to monitor Aβ fibrillization. This complex is not photoluminescent in aqueous solution nor in the presence of monomeric Aβ, but it presents a strong photoluminescence in the presence of Aβ fibril aggregates. One of the advantages of this metal complex is its large Stokes shift (180 nm). Furthermore, the long-lived photoluminescence lifetime of this ruthenium complex allows its use for the detection of fibrillar proteins in the presence of short-lived fluorescent backgrounds, using time-gating technology. We will present evidence of the advantages of dipyridophenazine ruthenium(II) complexes for monitoring protein fibrillization in highly fluorescent media.
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