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  • Title: Interaction of angiotensin II and atrial natriuretic peptide in the human fetoplacental unit.
    Author: McQueen J, Jardine A, Kingdom J, Templeton A, Whittle MJ, Connell JM.
    Journal: Am J Hypertens; 1990 Aug; 3(8 Pt 1):641-4. PubMed ID: 2171565.
    Abstract:
    We have identified two classes of membrane receptor for atrial natriuretic peptide (KD (dissociation constant) 0.2, 70.1 nmol/L) and angiotensin II (KD 1.7 nmol/L, 15.2 nmol/L) in human fetoplacental vasculature. In addition, in the isolated perfused placenta atrial natriuretic peptide inhibited the vasoconstrictor action of angiotensin II. These findings suggest that atrial natriuretic factor may regulate fetoplacental blood flow.
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