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  • Title: [The role of the components of the cyclic nucleotide system in N-nitrosodiethylamine-induced hepatic carcinogenesis in rats].
    Author: Antonenko SG, Berdinskikh NK, Mishnaevskaia EG.
    Journal: Eksp Onkol; 1990; 12(5):18-21. PubMed ID: 2171896.
    Abstract:
    The content of cyclic nucleotides and activity cAMP- and cGMP-dependent PDE-ases have been studied in the rat liver and activity of NaF stimulated adenylate cyclase was studied in plasma membranes of the rat liver at late stages (2-5.5 months) of hepatocarcinogenesis induced by NDEA. A considerable decrease in the basal adenylate cyclase activity and NaF stimulated adenylate cyclase activity in plasma membranes of hepatomas in comparison with norm has been observed. During the hepatocarcinogenesis it was observed a decrease in the cAMP/cGMP ratio, an increase of the cAMP-dependent PDE-ase and a decrease in activity of cGMP-dependent PDE-ase in the rat hepatomas have been found.
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