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  • Title: Glucagon-like peptide-1(7-37) does not stimulate either hepatic glycogenolysis or ketogenesis.
    Author: Murayama Y, Kawai K, Suzuki S, Ohashi S, Yamashita K.
    Journal: Endocrinol Jpn; 1990 Apr; 37(2):293-7. PubMed ID: 2171922.
    Abstract:
    Recent Studies have demonstrated that glucagon-like peptide-1 (GLP)(7-37) has more potent insulinotropic activity than glucagon. We therefore examined the effect of GLP-1(7-37) on liver metabolism using rat liver perfusion system. Ten nM GLP-1(7-37) did not affect glucose, ketone body and cAMP outputs from the perfused liver. Whereas, the same dose of glucagon stimulated these outputs significantly. When 10 nM GLP-1(7-37) perfused 5 min before the administration of 10 nM glucagon, the above stimulatory effects of glucagon were not affected. These results indicate that truncated GLP-1 has no effect on hepatic glycogenolysis and ketogenesis dissociating from its potent insulinotropic activity.
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