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  • Title: Protective immunity against malaria by 'natural immunization': a question of dose, parasite diversity, or both?
    Author: Borrmann S, Matuschewski K.
    Journal: Curr Opin Immunol; 2011 Aug; 23(4):500-8. PubMed ID: 21719266.
    Abstract:
    Plasmodium undergoes an obligate liver phase before the onset of malaria, which is caused exclusively by cyclic propagation of the parasite inside erythrocytes. The diagnostically inaccessible and clinically silent pre-erythrocytic expansion phase is a promising target for inducing sterilizing immunity against reinfections. Recent studies in rodent and human malaria models called attention to the induction of potent protective immunity by administration of anti-malarial drugs during sporozoite exposure. Here, we review the concept of drug-mediated pathogen arrest as a natural immunization strategy. This previously unrecognized immunological benefit might also open new opportunities for population-wide presumptive drug administration as an adjunct malaria control tool.
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