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  • Title: Pseuduvarines A and B, two new cytotoxic dioxoaporphine alkaloids from Pseuduvaria rugosa.
    Author: Taha H, Hadi AH, Nordin N, Najmuldeen IA, Mohamad K, Shirota O, Nugroho AE, Piow WC, Kaneda T, Morita H.
    Journal: Chem Pharm Bull (Tokyo); 2011; 59(7):896-7. PubMed ID: 21720044.
    Abstract:
    Pseuduvarines A (1) and B (2), two new dioxoaporphine alkaloids with an amino moiety, were isolated from the stem bark of Pseuduvaria rugosa and their structures were elucidated by combination of 2D-NMR spectroscopic analysis. Pseuduvarines A (1) and B (2) showed cytotoxicity against MCF7, HepG2, and HL-60 (1: IC₅₀, 0.9, 21.7, and >50.0 µM, respectively, 2: IC₅₀ >50.0, 15.7, and 12.4 µM, respectively).
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