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  • Title: [Immunohistochemical detection of calmodulin. A contribution to the histogenetic classification of eccrine poroma and clear cell acanthoma].
    Author: Schaarschmidt H, Wollina U.
    Journal: Dermatol Monatsschr; 1990; 176(5-6):363-70. PubMed ID: 2172054.
    Abstract:
    In previous immunohistochemical studies calmodulin (CaM) was detected in the sweat duct. In further investigations we searched for CaM-reactivity in eccrine poromas and clear cell acanthomas. CaM was only detectable in whorl-like areas, so confirming the concept of a ductal origin of this tumor. CaM-reactivity was failing in both, intraepidermal and malignant eccrine poroma. Acanthomas with clear cell pattern failed to give uniform results, suggesting a heterogenous origin of clear cells in the tumours investigated.
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