These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Organocatalytic hydroacylation of unactivated alkenes.
    Author: DiRocco DA, Rovis T.
    Journal: Angew Chem Int Ed Engl; 2011 Aug 22; 50(35):7982-3. PubMed ID: 21721090.
    Abstract:
    N-Heterocyclic carbenes interact with aldehydes to generate the Breslow intermediate, a rendering of the prototypical electrophile into a nucleophile (umpolung). Recent work has indicated that these intermediates may also add to simple, unpolarized alkenes. The use of a chiral precatalyst leads to the generation of the derived adducts with high yields and very high selectivities.
    [Abstract] [Full Text] [Related] [New Search]