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  • Title: High-resolution extracellular stimulation of dispersed hippocampal culture with high-density CMOS multielectrode array based on non-Faradaic electrodes.
    Author: Lei N, Ramakrishnan S, Shi P, Orcutt JS, Yuste R, Kam LC, Shepard KL.
    Journal: J Neural Eng; 2011 Aug; 8(4):044003. PubMed ID: 21725154.
    Abstract:
    We introduce a method to electrically stimulate individual neurons at single-cell resolution in arbitrary spatiotemporal patterns with precise control over stimulation thresholds. By exploiting a custom microelectronic chip, up to 65,000 non-Faradaic electrodes can be uniquely addressed with electrode density exceeding 6500 electrodes mm(-2). We demonstrate extracellular stimulation of dispersed primary hippocampal neuronal cultures using the chip at single-cell resolution.
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