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  • Title: Synthesis, characterization, and antihyperglycemic activity of novel oxazolidine derivatives.
    Author: Selvam TP, Kumar PV, Ramu P, Kumar AS.
    Journal: Arch Pharm Res; 2011 Jun; 34(6):887-91. PubMed ID: 21725808.
    Abstract:
    A number of compounds have been prepared in order to improve pharmacological roles of antihyperglycemic activity. In the present paper, a series of 3-benzyl-2-(4'-substituted phenyl)-4(5H)-(4″-nitrophenyl amino)-1,3-oxazolidines (6a-e) were tested against hyperglycemia. Their antihyperglycemic activity was evaluated by streptozotocin (STZ) and sucrose-loaded (SLM) models. Compounds 6a, b, c, d, and e displayed significant reductions in blood glucose in the streptozotocin and sucrose loaded rat models. The purity of the synthesized compounds was characterized by means of IR, (1)H-NMR, mass spectral and elemental analysis.
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