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  • Title: Correlation of midtrimester amniotic fluid cytokine concentrations with adverse pregnancy outcome in terms of spontaneous abortion, preterm birth, and preeclampsia.
    Author: Bamberg C, Fotopoulou C, Thiem D, Roehr CC, Dudenhausen JW, Kalache KD.
    Journal: J Matern Fetal Neonatal Med; 2012 Jun; 25(6):812-7. PubMed ID: 21726173.
    Abstract:
    OBJECTIVE: To assess midtrimester amniotic fluid concentrations of three major proinflammatory cytokines (IL-6, IL-8, and TNF-α) in asymptomatic pregnancies with adverse outcomes. METHODS: A prospective follow up study at the Charité University Hospital, Berlin, Germany of women with uncomplicated singleton pregnancies at second trimester and amniocentesis. Concentrations of IL-6, IL-8, and TNF-α were measured by enzyme-linked immunosorbent assay following amniotic fluid assessment by midtrimester amniocentesis performed from gestation days 15 weeks 0 days up to 20 weeks 6 days. Values from normal pregnancies were compared to those from pregnancies having adverse outcomes of spontaneous abortion, preterm delivery, preeclampsia, or eclampsia. Main outcome measure IL-6, IL-8 and TNF-α in relation to adverse pregnancy outcome. RESULTS: A total of 298 consecutive patients were evaluated. Median patient age was 35 years (range 19-43). Controls consisted of 273 women who delivered without further complications after 37 weeks gestation. The range values of IL-6, IL-8, and TNF-α in the control group were 4.9-2620 pg/mL, 36.2-5843 pg/mL, and 8.0-28.2 pg/mL, respectively. Patients with adverse pregnancy outcome (n = 25) were classified into three groups: spontaneous abortion group (n = 4), preterm delivery group (n = 17), and preeclampsia/eclampsia group (n = 4). There were no significant differences in IL-6, IL-8, and TNF-α between controls and study groups, regardless of the type of complication (p > 0.05). CONCLUSION: Midtrimester amniotic fluid concentrations of the proinflammatory cytokines IL-6, IL-8, and TNF-α are not predictive of adverse pregnancy outcome in terms of spontaneous abortion, preterm delivery or preeclampsia/eclampsia in our study population.
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