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  • Title: Localization of gene for human syndecan, an integral membrane proteoglycan and a matrix receptor, to chromosome 2.
    Author: Ala-Kapee M, Nevanlinna H, Mali M, Jalkanen M, Schröder J.
    Journal: Somat Cell Mol Genet; 1990 Sep; 16(5):501-5. PubMed ID: 2173154.
    Abstract:
    Syndecan, a cell surface proteoglycan, is an integral membrane protein acting as a receptor for the extracellular matrix. For chromosomal localization of the human syndecan gene, a panel of mouse-human somatic cell hybrids was analyzed by Southern blotting using the cDNA probe for human syndecan. The hybrids were karyotyped at the time of DNA extraction. A band corresponding to the human syndecan gene in Southern blots was found only in a hybrid cell line containing human chromosome 2. This hybrid was subcloned and its subclones were analyzed by Southern blotting and karyotyped. Subclones carrying human chromosome 2 contained the syndecan gene, while subclones not carrying this chromosome did not. The human syndecan gene is thus assigned to chromosome 2.
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