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  • Title: Synthesis of the tricyclic core of labiatin A and australin A.
    Author: Clark JS, Vignard D, Parkin A.
    Journal: Org Lett; 2011 Aug 05; 13(15):3980-3. PubMed ID: 21732661.
    Abstract:
    A concise synthesis of the tricyclic core of the marine diterpene natural products labiatin A and australin A has been accomplished. The key ring-forming transformation is a cascade reaction comprising generation of a copper carbenoid from a diazo ketone, intramolecular reaction of the carbenoid with a cyclic ether, and rearrangement of the resulting free oxonium ylide or its metal-bound equivalent with ring expansion of the original cyclic ether.
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