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  • Title: Patients with palmoplantar pustulosis have increased IL-17 and IL-22 levels both in the lesion and serum.
    Author: Murakami M, Hagforsen E, Morhenn V, Ishida-Yamamoto A, Iizuka H.
    Journal: Exp Dermatol; 2011 Oct; 20(10):845-7. PubMed ID: 21732985.
    Abstract:
    Recent findings about the pathogenesis of pustulosis palmaris et plantaris (PPP), also known as palmoplantar pustulosis, suggest that IL-17 expression in the acrosyringium as well as infiltration of IL-17 positive cells, e.g. Langerhans cells may play important roles. However, to date, it has not been established whether circulating IL-17 related cytokines are involved in PPP. We studied the circulating IL-17 related cytokines as well as the mRNA levels in lesional skin. IL-17 related cytokine mRNAs were increased in the PPP lesions compared with the control tissues (five patients vs five controls). The serum levels of TNF-alpha, IL-17, IL-22 and IFN-gamma also were significantly increased in PPP, but not IL-23 and IL-8 (48 patients vs 20 controls). Our findings document that not only the serum IL-17 but also tissue IL-17 are elevated in PPP and may be in the pathogenesis of this disorder.
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