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  • Title: Amide H/D exchange in the thermal transition of bovine pancreatic ribonuclease A.
    Author: Talluri S, Scheraga HA.
    Journal: Biochem Biophys Res Commun; 1990 Oct 30; 172(2):800-3. PubMed ID: 2173581.
    Abstract:
    The H/D exchange behavior of RNase A at pH 2.5 at a number of temperatures spanning the thermal transition region has been examined by NMR spectroscopy. The amide proton of V116 has a slow rate of H/D exchange even at temperatures above the midpoint of the thermal transition. The H/D exchange behavior of the peptide corresponding to residues 105-124 of RNase A and the peptide corresponding to residues 115-117 is compared with that of RNase A, showing that folding/unfolding cannot be described by a two-state model, and that both short- and long-range interactions are responsible for the slow rate of H/D exchange.
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